Toward a ToxAtlas of Carbon-Based Nanomaterials: Single-Cell RNA Sequencing Reveals Initiating Cell Circuits in Pulmonary Inflammation

Carola Voss; Lianyong Han; Meshal Ansari; Maximilian Strunz; Verena Haefner; Ilias Angelidis; Christoph H. Mayr; Trine Berthing; Qiaoxia Zhou; Eva M. Guenther; Osama Huzain; Otmar Schmid; Ulla Vogel; Janine Gote-Schniering; Svenja Gaedcke; Fabian J. Theis; Herbert B. Schiller; Tobias Stoeger

doi:10.1021/acsnano.5c12054

Toward a ToxAtlas of Carbon-Based Nanomaterials: Single-Cell RNA Sequencing Reveals Initiating Cell Circuits in Pulmonary Inflammation

Carola Voss
, Lianyong Han
, Meshal Ansari
, Maximilian Strunz
, Verena Haefner
, Ilias Angelidis
, Christoph H. Mayr
, Trine Berthing
, Qiaoxia Zhou
, Eva M. Guenther
, Osama Huzain
, Otmar Schmid
, Ulla Vogel
, Janine Gote-Schniering
, Svenja Gaedcke
, Fabian J. Theis
, Herbert B. Schiller
, Tobias Stoeger

Helmholtz Zentrum München - German Research Center for Environmental Health
Member of the German Center for Lung Research (DZL)
Hannover Medical School
Hannover Re
National Research Centre for the Working Environment
University of Bern
Technical University of Munich
Wellcome Trust Genome Campus
Ludwig Maximilian University of Munich

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	39139-39156
Number of pages	18
Journal	ACS Nano
Volume	19
Issue number	45
DOIs	https://doi.org/10.1021/acsnano.5c12054
State	Published - Nov 18 2025
Externally published	Yes

ASJC Scopus Subject Areas

General Materials Science
General Engineering
General Physics and Astronomy

Keywords

mode of action (MoA)/cell circuits
nanomaterials
predictive assays
pulmonary inflammation
respiratory toxicology
scRNA-seq
ToxAtlas

Access to Document

10.1021/acsnano.5c12054

Cite this

Voss, C., Han, L., Ansari, M., Strunz, M., Haefner, V., Angelidis, I., Mayr, C. H., Berthing, T., Zhou, Q., Guenther, E. M., Huzain, O., Schmid, O., Vogel, U., Gote-Schniering, J., Gaedcke, S., Theis, F. J., Schiller, H. B., & Stoeger, T. (2025). Toward a ToxAtlas of Carbon-Based Nanomaterials: Single-Cell RNA Sequencing Reveals Initiating Cell Circuits in Pulmonary Inflammation. ACS Nano, 19(45), 39139-39156. https://doi.org/10.1021/acsnano.5c12054

Voss, C, Han, L, Ansari, M, Strunz, M, Haefner, V, Angelidis, I, Mayr, CH, Berthing, T, Zhou, Q, Guenther, EM, Huzain, O, Schmid, O, Vogel, U, Gote-Schniering, J, Gaedcke, S, Theis, FJ, Schiller, HB & Stoeger, T 2025, 'Toward a ToxAtlas of Carbon-Based Nanomaterials: Single-Cell RNA Sequencing Reveals Initiating Cell Circuits in Pulmonary Inflammation', ACS Nano, vol. 19, no. 45, pp. 39139-39156. https://doi.org/10.1021/acsnano.5c12054

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keywords = "mode of action (MoA)/cell circuits, nanomaterials, predictive assays, pulmonary inflammation, respiratory toxicology, scRNA-seq, ToxAtlas",

author = "Carola Voss and Lianyong Han and Meshal Ansari and Maximilian Strunz and Verena Haefner and Ilias Angelidis and Mayr, \{Christoph H.\} and Trine Berthing and Qiaoxia Zhou and Guenther, \{Eva M.\} and Osama Huzain and Otmar Schmid and Ulla Vogel and Janine Gote-Schniering and Svenja Gaedcke and Theis, \{Fabian J.\} and Schiller, \{Herbert B.\} and Tobias Stoeger",

note = "Publisher Copyright: {\textcopyright} 2025 The Authors. Published by American Chemical Society",

year = "2025",

month = nov,

day = "18",

doi = "10.1021/acsnano.5c12054",

language = "English",

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AU - Voss, Carola

AU - Han, Lianyong

AU - Ansari, Meshal

AU - Strunz, Maximilian

AU - Haefner, Verena

AU - Angelidis, Ilias

AU - Mayr, Christoph H.

AU - Berthing, Trine

AU - Zhou, Qiaoxia

AU - Guenther, Eva M.

AU - Huzain, Osama

AU - Schmid, Otmar

AU - Vogel, Ulla

AU - Gote-Schniering, Janine

AU - Gaedcke, Svenja

AU - Theis, Fabian J.

AU - Schiller, Herbert B.

AU - Stoeger, Tobias

PY - 2025/11/18

Y1 - 2025/11/18

KW - mode of action (MoA)/cell circuits

KW - nanomaterials

KW - predictive assays

KW - pulmonary inflammation

KW - respiratory toxicology

KW - scRNA-seq

KW - ToxAtlas

UR - https://www.scopus.com/pages/publications/105022059614

UR - https://www.scopus.com/pages/publications/105022059614#tab=citedBy

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DO - 10.1021/acsnano.5c12054

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AN - SCOPUS:105022059614

SN - 1936-0851

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JO - ACS Nano

JF - ACS Nano

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ER -

Toward a ToxAtlas of Carbon-Based Nanomaterials: Single-Cell RNA Sequencing Reveals Initiating Cell Circuits in Pulmonary Inflammation

ASJC Scopus Subject Areas

Keywords

Access to Document

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