Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13

Kevin D. Freeman-Cook; Lawrence A. Reiter; Mark C. Noe; Amy S. Antipas; Dennis E. Danley; Kaushik Datta; James T. Downs; Shane Eisenbeis; James D. Eskra; David J. Garmene; Elaine M. Greer; Richard J. Griffiths; Roberto Guzman; Joel R. Hardink; Fouad Janat; Christopher S. Jones; Gary J. Martinelli; Peter G. Mitchell; Ellen R. Laird; Jennifer L. Liras; Lori L. Lopresti-Morrow; Jayvardhan Pandit; Usa D. Reilly; Donald Robertson; Marcie L. Vaughn-Bowser; Lilli A. Wolf-Gouviea; Sue A. Yocum

doi:10.1016/j.bmcl.2007.09.085

Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13

Kevin D. Freeman-Cook
, Lawrence A. Reiter
, Mark C. Noe
, Amy S. Antipas
, Dennis E. Danley
, Kaushik Datta
, James T. Downs
, Shane Eisenbeis
, James D. Eskra
, David J. Garmene
, Elaine M. Greer
, Richard J. Griffiths
, Roberto Guzman
, Joel R. Hardink
, Fouad Janat
, Christopher S. Jones
, Gary J. Martinelli
, Peter G. Mitchell
, Ellen R. Laird
, Jennifer L. Liras

Lori L. Lopresti-Morrow, Jayvardhan Pandit, Usa D. Reilly, Donald Robertson, Marcie L. Vaughn-Bowser, Lilli A. Wolf-Gouviea, Sue A. Yocum

Pfizer

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	6529-6534
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	17
Issue number	23
DOIs	https://doi.org/10.1016/j.bmcl.2007.09.085
State	Published - Dec 1 2007
Externally published	Yes

ASJC Scopus Subject Areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Keywords

Collagenase-3
Matrix metalloprotease
MMP-13
Pyrimidinetrione

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10.1016/j.bmcl.2007.09.085

Cite this

Freeman-Cook, K. D., Reiter, L. A., Noe, M. C., Antipas, A. S., Danley, D. E., Datta, K., Downs, J. T., Eisenbeis, S., Eskra, J. D., Garmene, D. J., Greer, E. M., Griffiths, R. J., Guzman, R., Hardink, J. R., Janat, F., Jones, C. S., Martinelli, G. J., Mitchell, P. G., Laird, E. R., ... Yocum, S. A. (2007). Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13. Bioorganic and Medicinal Chemistry Letters, 17(23), 6529-6534. https://doi.org/10.1016/j.bmcl.2007.09.085

Freeman-Cook, KD, Reiter, LA, Noe, MC, Antipas, AS, Danley, DE, Datta, K, Downs, JT, Eisenbeis, S, Eskra, JD, Garmene, DJ, Greer, EM, Griffiths, RJ, Guzman, R, Hardink, JR, Janat, F, Jones, CS, Martinelli, GJ, Mitchell, PG, Laird, ER, Liras, JL, Lopresti-Morrow, LL, Pandit, J, Reilly, UD, Robertson, D, Vaughn-Bowser, ML, Wolf-Gouviea, LA & Yocum, SA 2007, 'Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13', Bioorganic and Medicinal Chemistry Letters, vol. 17, no. 23, pp. 6529-6534. https://doi.org/10.1016/j.bmcl.2007.09.085

@article{b33adeb35ad54d0f8ff8e854b0752948,

title = "Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13",

keywords = "Collagenase-3, Matrix metalloprotease, MMP-13, Pyrimidinetrione",

author = "Freeman-Cook, \{Kevin D.\} and Reiter, \{Lawrence A.\} and Noe, \{Mark C.\} and Antipas, \{Amy S.\} and Danley, \{Dennis E.\} and Kaushik Datta and Downs, \{James T.\} and Shane Eisenbeis and Eskra, \{James D.\} and Garmene, \{David J.\} and Greer, \{Elaine M.\} and Griffiths, \{Richard J.\} and Roberto Guzman and Hardink, \{Joel R.\} and Fouad Janat and Jones, \{Christopher S.\} and Martinelli, \{Gary J.\} and Mitchell, \{Peter G.\} and Laird, \{Ellen R.\} and Liras, \{Jennifer L.\} and Lopresti-Morrow, \{Lori L.\} and Jayvardhan Pandit and Reilly, \{Usa D.\} and Donald Robertson and Vaughn-Bowser, \{Marcie L.\} and Wolf-Gouviea, \{Lilli A.\} and Yocum, \{Sue A.\}",

year = "2007",

month = dec,

day = "1",

doi = "10.1016/j.bmcl.2007.09.085",

language = "English",

volume = "17",

pages = "6529--6534",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

number = "23",

}

TY - JOUR

T1 - Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13

AU - Freeman-Cook, Kevin D.

AU - Reiter, Lawrence A.

AU - Noe, Mark C.

AU - Antipas, Amy S.

AU - Danley, Dennis E.

AU - Datta, Kaushik

AU - Downs, James T.

AU - Eisenbeis, Shane

AU - Eskra, James D.

AU - Garmene, David J.

AU - Greer, Elaine M.

AU - Griffiths, Richard J.

AU - Guzman, Roberto

AU - Hardink, Joel R.

AU - Janat, Fouad

AU - Jones, Christopher S.

AU - Martinelli, Gary J.

AU - Mitchell, Peter G.

AU - Laird, Ellen R.

AU - Liras, Jennifer L.

AU - Lopresti-Morrow, Lori L.

AU - Pandit, Jayvardhan

AU - Reilly, Usa D.

AU - Robertson, Donald

AU - Vaughn-Bowser, Marcie L.

AU - Wolf-Gouviea, Lilli A.

AU - Yocum, Sue A.

PY - 2007/12/1

Y1 - 2007/12/1

KW - Collagenase-3

KW - Matrix metalloprotease

KW - MMP-13

KW - Pyrimidinetrione

UR - https://www.scopus.com/pages/publications/35648973186

UR - https://www.scopus.com/pages/publications/35648973186#tab=citedBy

U2 - 10.1016/j.bmcl.2007.09.085

DO - 10.1016/j.bmcl.2007.09.085

M3 - Article

C2 - 17935984

AN - SCOPUS:35648973186

SN - 0960-894X

VL - 17

SP - 6529

EP - 6534

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 23

ER -

Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13

ASJC Scopus Subject Areas

Keywords

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