Abstract
Ni(II) complexes of ortho-naphthaquinone thiosemicarbazone and semicarbazone were synthesized and spectroscopically characterized. the X-ray crystal structure of both the complexes describe a distorted octahedral coordination with two tridentate mono-deprotonated ligands. in vitro anticancer studies on MCF-7 human breast cancer cells reveal that the semicarbazone derivative along with its nickel complex is more active in the inhibition of cell proliferation than the thiosemicarbazone analogue.
| Original language | American English |
|---|---|
| Journal | Journal of Inorganic Biochemistry |
| Volume | 99 |
| DOIs | |
| State | Published - Jul 1 2005 |
Keywords
- Antineoplastic Agents
- Cell Line, Tumor
- Cell Proliferation
- Crystallography, X-Ray
- Drug Screening Assays, Antitumor
- Humans
- Ligands
- Magnetic Resonance Spectroscopy
- Models, Molecular
- Molecular Structure
- Naphthoquinones
- Nickel
- Organometallic Compounds
- Semicarbazones
- Spectrophotometry, Infrared
- Spectrophotometry, Ultraviolet
- Thiosemicarbazones, Mink cell focus-forming virus
- X ray analysis
- antineoplastic activity
- antineoplastic agent
- biological activity
- cancer inhibition
- cell proliferation
- cell strain MCF 7
- crystal structure
- drug structure
- drug synthesis
- human
- human cell
- naphthaquinone thiosemicarbazone
- nickel complex
- nickel(naphthaquinone semicarbazone)
- nickel(naphthaquinone thiosemicarbazone)
- semicarbazone
- semicarbazone derivative
- spectroscopy
- unclassified drug
Disciplines
- Chemistry
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