N-Heterocyclic Carbene-Catalyzed Trifluoromethylation of Aromatic N-Tosylaldimines

Prakash Reddy; Meher Perambuduru; Jatin Mehta

doi:10.1007/s11244-018-0912-7

N-Heterocyclic Carbene-Catalyzed Trifluoromethylation of Aromatic N-Tosylaldimines

Prakash Reddy
, Meher Perambuduru
, Jatin Mehta

Missouri University of Science and Technology

Research output: Contribution to journal › Article › peer-review

Abstract

Nucleophilic trifluoromethylation of aromatic N-tosylaldimines has been achieved using trifluoromethyltrimethylsilane (TMSCF ₃ ) in the presence of the in situ generated N-heterocyclic carbene catalysts. Aromatic N-tosylaldimines with electron-withdrawing as well as electron-donating groups on the aryl ring afforded the corresponding trifluoromethylated sulfonamides in moderate to good yields.

Original language	American English
Journal	Topics in Catalysis
Volume	61
DOIs	https://doi.org/10.1007/s11244-018-0912-7
State	Published - Jun 1 2018

Keywords

Aldimines
Catalysis
Imidazolium
N-Heterocyclic carbene
TMSCF3
Trifluoromethylation

Disciplines

Chemistry

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https://doi.org/10.1007/s11244-018-0912-7

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title = "N-Heterocyclic Carbene-Catalyzed Trifluoromethylation of Aromatic N-Tosylaldimines",

abstract = " Nucleophilic trifluoromethylation of aromatic N-tosylaldimines has been achieved using trifluoromethyltrimethylsilane (TMSCF 3 ) in the presence of the in situ generated N-heterocyclic carbene catalysts. Aromatic N-tosylaldimines with electron-withdrawing as well as electron-donating groups on the aryl ring afforded the corresponding trifluoromethylated sulfonamides in moderate to good yields.",

keywords = "Aldimines, Catalysis, Imidazolium, N-Heterocyclic carbene, TMSCF3, Trifluoromethylation",

author = "Prakash Reddy and Meher Perambuduru and Jatin Mehta",

year = "2018",

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doi = "10.1007/s11244-018-0912-7",

language = "American English",

volume = "61",

journal = "Topics in Catalysis",

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T1 - N-Heterocyclic Carbene-Catalyzed Trifluoromethylation of Aromatic N-Tosylaldimines

AU - Reddy, Prakash

AU - Perambuduru, Meher

AU - Mehta, Jatin

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Nucleophilic trifluoromethylation of aromatic N-tosylaldimines has been achieved using trifluoromethyltrimethylsilane (TMSCF 3 ) in the presence of the in situ generated N-heterocyclic carbene catalysts. Aromatic N-tosylaldimines with electron-withdrawing as well as electron-donating groups on the aryl ring afforded the corresponding trifluoromethylated sulfonamides in moderate to good yields.

AB - Nucleophilic trifluoromethylation of aromatic N-tosylaldimines has been achieved using trifluoromethyltrimethylsilane (TMSCF 3 ) in the presence of the in situ generated N-heterocyclic carbene catalysts. Aromatic N-tosylaldimines with electron-withdrawing as well as electron-donating groups on the aryl ring afforded the corresponding trifluoromethylated sulfonamides in moderate to good yields.

KW - Aldimines

KW - Catalysis

KW - Imidazolium

KW - N-Heterocyclic carbene

KW - TMSCF3

KW - Trifluoromethylation

UR - https://scholarsmine.mst.edu/chem_facwork/2914

UR - https://doi.org/10.1007/s11244-018-0912-7

U2 - 10.1007/s11244-018-0912-7

DO - 10.1007/s11244-018-0912-7

M3 - Article

VL - 61

JO - Topics in Catalysis

JF - Topics in Catalysis

ER -

N-Heterocyclic Carbene-Catalyzed Trifluoromethylation of Aromatic N-Tosylaldimines

Abstract

Keywords

Disciplines

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