Micromachined Nanoporous Membranes For Blood Oxygenation Systems

Vijayakrishnan Ambravaneswaran; Susheil Uttamaraj; Zeynep Çelik-Butler; Robert C. Eberhart; Charles J. Chuong; Richard E. Billo; Michael A. Savitt

doi:10.1109/NANO.2008.66

Micromachined Nanoporous Membranes For Blood Oxygenation Systems

Vijayakrishnan Ambravaneswaran
, Susheil Uttamaraj
, Zeynep Çelik-Butler
, Robert C. Eberhart
, Charles J. Chuong
, Richard E. Billo
, Michael A. Savitt

Research output: Contribution to journal › Article › peer-review

Abstract

Nanostructured membranes with precisely engineered nanopores were fabricated on a thin silicon nitride membrane, using a combination of bulk micromachining and focused-ion-beam drilling. These membranes are designed to preserve microscale blood channel dimensions, thereby permitting the red cell shape change that enhances gas exchange in the pulmonary capillary. The membranes were tested for their mechanical stability and the results were verified with finite element analysis. Initial studies have proven the membranes to be robust, and capable of withstanding pressures typically experienced in blood oxygenator channels. A novel MEMS-based blood oxygenation system employing the nanoporous membranes is also presented. The oxygenation system is designed to have controlled blood and gas volumes for efficient blood oxygenation. © 2008 IEEE.

Original language	American English
Journal	2008 8th IEEE Conference on Nanotechnology, IEEE-NANO
DOIs	https://doi.org/10.1109/NANO.2008.66
State	Published - Jan 1 2008

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Aerospace Engineering
Mechanical Engineering

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title = "Micromachined Nanoporous Membranes For Blood Oxygenation Systems",

abstract = " Nanostructured membranes with precisely engineered nanopores were fabricated on a thin silicon nitride membrane, using a combination of bulk micromachining and focused-ion-beam drilling. These membranes are designed to preserve microscale blood channel dimensions, thereby permitting the red cell shape change that enhances gas exchange in the pulmonary capillary. The membranes were tested for their mechanical stability and the results were verified with finite element analysis. Initial studies have proven the membranes to be robust, and capable of withstanding pressures typically experienced in blood oxygenator channels. A novel MEMS-based blood oxygenation system employing the nanoporous membranes is also presented. The oxygenation system is designed to have controlled blood and gas volumes for efficient blood oxygenation. {\textcopyright} 2008 IEEE.",

author = "Vijayakrishnan Ambravaneswaran and Susheil Uttamaraj and Zeynep {\c C}elik-Butler and Eberhart, \{Robert C.\} and Chuong, \{Charles J.\} and Billo, \{Richard E.\} and Savitt, \{Michael A.\}",

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doi = "10.1109/NANO.2008.66",

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AU - Ambravaneswaran, Vijayakrishnan

AU - Uttamaraj, Susheil

AU - Çelik-Butler, Zeynep

AU - Eberhart, Robert C.

AU - Chuong, Charles J.

AU - Billo, Richard E.

AU - Savitt, Michael A.

PY - 2008/1/1

Y1 - 2008/1/1

N2 - Nanostructured membranes with precisely engineered nanopores were fabricated on a thin silicon nitride membrane, using a combination of bulk micromachining and focused-ion-beam drilling. These membranes are designed to preserve microscale blood channel dimensions, thereby permitting the red cell shape change that enhances gas exchange in the pulmonary capillary. The membranes were tested for their mechanical stability and the results were verified with finite element analysis. Initial studies have proven the membranes to be robust, and capable of withstanding pressures typically experienced in blood oxygenator channels. A novel MEMS-based blood oxygenation system employing the nanoporous membranes is also presented. The oxygenation system is designed to have controlled blood and gas volumes for efficient blood oxygenation. © 2008 IEEE.

AB - Nanostructured membranes with precisely engineered nanopores were fabricated on a thin silicon nitride membrane, using a combination of bulk micromachining and focused-ion-beam drilling. These membranes are designed to preserve microscale blood channel dimensions, thereby permitting the red cell shape change that enhances gas exchange in the pulmonary capillary. The membranes were tested for their mechanical stability and the results were verified with finite element analysis. Initial studies have proven the membranes to be robust, and capable of withstanding pressures typically experienced in blood oxygenator channels. A novel MEMS-based blood oxygenation system employing the nanoporous membranes is also presented. The oxygenation system is designed to have controlled blood and gas volumes for efficient blood oxygenation. © 2008 IEEE.

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U2 - 10.1109/NANO.2008.66

DO - 10.1109/NANO.2008.66

M3 - Article

JO - 2008 8th IEEE Conference on Nanotechnology, IEEE-NANO

JF - 2008 8th IEEE Conference on Nanotechnology, IEEE-NANO

ER -

Micromachined Nanoporous Membranes For Blood Oxygenation Systems

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