L1 (LINE-1) Retrotransposon Diversity Differs Dramatically between Mammals and Fish

Anthony V. Furano; David D. Duvernell; Stephane Boissinot

doi:10.1016/j.tig.2003.11.006

L1 (LINE-1) Retrotransposon Diversity Differs Dramatically between Mammals and Fish

Anthony V. Furano
, David D. Duvernell
, Stephane Boissinot

Biological Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

L1 retrotransposons replicate (amplify) by copying (reverse transcribing) their RNA transcript into genomic DNA. The evolutionary history of L1 in mammals has been unique. In mice and humans ~80 million years of L1 evolution and replication produced a single evolutionary lineage of L1 elements while generating ~20% of the genomic mass in each species. By contrast, zebrafish contain >30 distinct L1 lineages that have generated approximately one-tenth as much DNA. We contend that, by becoming far more permissive of interspersed repeated DNA than other organisms, mammals are conducive to competition between L1 families for replicative dominance, and that this competition, perhaps for the host factors required for L1 replication, results in a single L1 lineage.

Original language	American English
Journal	Trends in Genetics
Volume	20
DOIs	https://doi.org/10.1016/j.tig.2003.11.006
State	Published - Jan 1 2004

Keywords

Danio Rerio
Evolution
Fish
Gene Replication
Genetic Variability
Human
Long Interspersed Repeat
Mammal
Mammalia
Nonhuman
Nucleotide Sequence
Phylogeny
Priority Journal
Retroposon
Reverse Transcription
Species Difference
Variation (genetics)
Zebra Fish

Disciplines

Biology

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https://doi.org/10.1016/j.tig.2003.11.006

Cite this

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title = "L1 (LINE-1) Retrotransposon Diversity Differs Dramatically between Mammals and Fish",

abstract = " L1 retrotransposons replicate (amplify) by copying (reverse transcribing) their RNA transcript into genomic DNA. The evolutionary history of L1 in mammals has been unique. In mice and humans \textasciitilde{}80 million years of L1 evolution and replication produced a single evolutionary lineage of L1 elements while generating \textasciitilde{}20\% of the genomic mass in each species. By contrast, zebrafish contain >30 distinct L1 lineages that have generated approximately one-tenth as much DNA. We contend that, by becoming far more permissive of interspersed repeated DNA than other organisms, mammals are conducive to competition between L1 families for replicative dominance, and that this competition, perhaps for the host factors required for L1 replication, results in a single L1 lineage.",

keywords = "Danio Rerio, Evolution, Fish, Gene Replication, Genetic Variability, Human, Long Interspersed Repeat, Mammal, Mammalia, Nonhuman, Nucleotide Sequence, Phylogeny, Priority Journal, Retroposon, Reverse Transcription, Species Difference, Variation (genetics), Zebra Fish",

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year = "2004",

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doi = "10.1016/j.tig.2003.11.006",

language = "American English",

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T1 - L1 (LINE-1) Retrotransposon Diversity Differs Dramatically between Mammals and Fish

AU - Furano, Anthony V.

AU - Duvernell, David D.

AU - Boissinot, Stephane

PY - 2004/1/1

Y1 - 2004/1/1

N2 - L1 retrotransposons replicate (amplify) by copying (reverse transcribing) their RNA transcript into genomic DNA. The evolutionary history of L1 in mammals has been unique. In mice and humans ~80 million years of L1 evolution and replication produced a single evolutionary lineage of L1 elements while generating ~20% of the genomic mass in each species. By contrast, zebrafish contain >30 distinct L1 lineages that have generated approximately one-tenth as much DNA. We contend that, by becoming far more permissive of interspersed repeated DNA than other organisms, mammals are conducive to competition between L1 families for replicative dominance, and that this competition, perhaps for the host factors required for L1 replication, results in a single L1 lineage.

AB - L1 retrotransposons replicate (amplify) by copying (reverse transcribing) their RNA transcript into genomic DNA. The evolutionary history of L1 in mammals has been unique. In mice and humans ~80 million years of L1 evolution and replication produced a single evolutionary lineage of L1 elements while generating ~20% of the genomic mass in each species. By contrast, zebrafish contain >30 distinct L1 lineages that have generated approximately one-tenth as much DNA. We contend that, by becoming far more permissive of interspersed repeated DNA than other organisms, mammals are conducive to competition between L1 families for replicative dominance, and that this competition, perhaps for the host factors required for L1 replication, results in a single L1 lineage.

KW - Danio Rerio

KW - Evolution

KW - Fish

KW - Gene Replication

KW - Genetic Variability

KW - Human

KW - Long Interspersed Repeat

KW - Mammal

KW - Mammalia

KW - Nonhuman

KW - Nucleotide Sequence

KW - Phylogeny

KW - Priority Journal

KW - Retroposon

KW - Reverse Transcription

KW - Species Difference

KW - Variation (genetics)

KW - Zebra Fish

UR - https://scholarsmine.mst.edu/biosci_facwork/120

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DO - 10.1016/j.tig.2003.11.006

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VL - 20

JO - Trends in Genetics

JF - Trends in Genetics

ER -

L1 (LINE-1) Retrotransposon Diversity Differs Dramatically between Mammals and Fish

Abstract

Keywords

Disciplines

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