In Vitro Assessment of Protamine Toxicity with Neural Cells, Its Therapeutic Potential to Counter Chondroitin Sulfate Mediated Neuron Inhibition, and Its Effects on Reactive Astrocytes

Derek W. Nelson; Jessica L. Funnell; Conrad H. Cheung; Geraldine B. Quinones; Christina S. Mendoza; Marvin Bentley; Ryan J. Gilbert

doi:10.1002/adtp.202300242

In Vitro Assessment of Protamine Toxicity with Neural Cells, Its Therapeutic Potential to Counter Chondroitin Sulfate Mediated Neuron Inhibition, and Its Effects on Reactive Astrocytes

Derek W. Nelson
, Jessica L. Funnell
, Conrad H. Cheung
, Geraldine B. Quinones
, Christina S. Mendoza
, Marvin Bentley
, Ryan J. Gilbert

Rensselaer Polytechnic Institute
Department of Biomedical Engineering
Department of Veterans Affairs

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	2300242
Journal	Advanced Therapeutics
Volume	7
Issue number	2
DOIs	https://doi.org/10.1002/adtp.202300242
State	Published - Feb 2024
Externally published	Yes

ASJC Scopus Subject Areas

Medicine (miscellaneous)
Pharmacology
Pharmaceutical Science
Genetics(clinical)
Biochemistry, medical
Pharmacology (medical)

Keywords

astrocyte reactivity
drug toxicity
neurotherapy
protamine sulfate salt
traumatic central nervous system injury

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10.1002/adtp.202300242

Cite this

Nelson, D. W., Funnell, J. L., Cheung, C. H., Quinones, G. B., Mendoza, C. S., Bentley, M., & Gilbert, R. J. (2024). In Vitro Assessment of Protamine Toxicity with Neural Cells, Its Therapeutic Potential to Counter Chondroitin Sulfate Mediated Neuron Inhibition, and Its Effects on Reactive Astrocytes. Advanced Therapeutics, 7(2), Article 2300242. https://doi.org/10.1002/adtp.202300242

In Vitro Assessment of Protamine Toxicity with Neural Cells, Its Therapeutic Potential to Counter Chondroitin Sulfate Mediated Neuron Inhibition, and Its Effects on Reactive Astrocytes. / Nelson, Derek W.; Funnell, Jessica L.; Cheung, Conrad H. et al.
In: Advanced Therapeutics, Vol. 7, No. 2, 2300242, 02.2024.

Research output: Contribution to journal › Article › peer-review

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AU - Cheung, Conrad H.

AU - Quinones, Geraldine B.

AU - Mendoza, Christina S.

AU - Bentley, Marvin

AU - Gilbert, Ryan J.

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KW - neurotherapy

KW - protamine sulfate salt

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In Vitro Assessment of Protamine Toxicity with Neural Cells, Its Therapeutic Potential to Counter Chondroitin Sulfate Mediated Neuron Inhibition, and Its Effects on Reactive Astrocytes

ASJC Scopus Subject Areas

Keywords

Access to Document

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