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Implication of Oncogenic Signaling Pathways as a Treatment Strategy for Neurodegenerative Disorders -- Contemporary Approaches

  • Adrian Sieradzki
  • , Bharat Bhushan Yendluri
  • , Hector H. Palacios
  • , Kalpana Parvathaneni
  • , Prakash Reddy
  • , Mark E. Obrenovich
  • , Kazimierz Ga̧siorowski
  • , Jerzy Leszek
  • , Gjumrakch M. Aliev

Research output: Contribution to journalArticlepeer-review

Abstract

Recent evidence has associated the aberrant, proximal re-expression of various cell cycle control elements with neuronal cell vulnerability in Alzheimer's and Parkinson's diseases, as a common chronic neurodegeneration. This phenomenon associated with oncogenic transduction pathway activation has attracted the interest of scientists all over the world for a few years now. The purpose of this paper is to outline areas of research related to oncogenic factors or medicines in the context of potential applications for future treatment of the above mentioned chronic and, largely, incurable diseases.

Original languageAmerican English
JournalCNS and Neurological Disorders - Drug Targets
Volume10
DOIs
StatePublished - Mar 1 2011

Keywords

  • Alzheimer's disease
  • Cell cycle
  • Mitochondria
  • Oncogenes
  • Parkinson's disease

Disciplines

  • Chemistry

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