¹⁶⁶Holmium-Containing Glass for Internal Radiotherapy of Tumors

Roger F. Brown; Lisa C. Lindesmith; D. E. Day

doi:10.1016/0883-2897(91)90018-G

¹⁶⁶Holmium-Containing Glass for Internal Radiotherapy of Tumors

Roger F. Brown
, Lisa C. Lindesmith
, D. E. Day

Research output: Contribution to journal › Article › peer-review

Abstract

Aluminosilicate glass containing the β-emitter ¹⁶⁶ Ho was tested for tumor cell killing effectiveness with the BT-20 human mammary carcinoma cell line as a model. Incubation of BT-20 cells with ¹⁶⁶ Ho glass partially inhibited DNA replication and completely blocked growth in cells located within 1.0 mm of the radioactive fiber. Growth of BT-20 tumor xenografts in nude mice was dramatically inhibited by injection of 2-5 μm fragments of ¹⁶⁶ Ho glass (200 μ Ci/tumor). The results suggest that ¹⁶⁶ Ho glass would be an effective modality for deposition of intense β ^- radiation for localized internal radiotherapy of tumors.

Original language	American English
Journal	International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology
Volume	18
DOIs	https://doi.org/10.1016/0883-2897(91)90018-G
State	Published - Jan 1 1991

Keywords

glass
holmium 166
unclassified drug
DNA
radioisotope
animal experiment
breast carcinoma
cancer cell culture
cancer graft
controlled study
female
human cell
interstitial radiation
nude mouse
animal
brachytherapy
breast tumor
cancer transplantation
cell survival
metabolism
radiation exposure
Brachytherapy
Breast Neoplasms

Disciplines

Biology
Ceramic Materials

Access to Document

10.1016/0883-2897(91)90018-GLicense: CC BY

http://www.ncbi.nlm.nih.gov/pubmed/1787088

Cite this

@article{5ec6557aac364f2d8b497c94cbf05c3b,

title = "¹⁶⁶Holmium-Containing Glass for Internal Radiotherapy of Tumors",

abstract = " Aluminosilicate glass containing the β-emitter 166 Ho was tested for tumor cell killing effectiveness with the BT-20 human mammary carcinoma cell line as a model. Incubation of BT-20 cells with 166 Ho glass partially inhibited DNA replication and completely blocked growth in cells located within 1.0 mm of the radioactive fiber. Growth of BT-20 tumor xenografts in nude mice was dramatically inhibited by injection of 2-5 μm fragments of 166 Ho glass (200 μ Ci/tumor). The results suggest that 166 Ho glass would be an effective modality for deposition of intense β - radiation for localized internal radiotherapy of tumors.",

keywords = "glass, holmium 166, unclassified drug, DNA, radioisotope, animal experiment, breast carcinoma, cancer cell culture, cancer graft, controlled study, female, human cell, interstitial radiation, nude mouse, animal, brachytherapy, breast tumor, cancer transplantation, cell survival, metabolism, radiation exposure, Brachytherapy, Breast Neoplasms",

author = "Brown, \{Roger F.\} and Lindesmith, \{Lisa C.\} and Day, \{D. E.\}",

year = "1991",

month = jan,

day = "1",

doi = "10.1016/0883-2897(91)90018-G",

language = "American English",

volume = "18",

journal = "International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology",

}

TY - JOUR

T1 - ¹⁶⁶Holmium-Containing Glass for Internal Radiotherapy of Tumors

AU - Brown, Roger F.

AU - Lindesmith, Lisa C.

AU - Day, D. E.

PY - 1991/1/1

Y1 - 1991/1/1

N2 - Aluminosilicate glass containing the β-emitter 166 Ho was tested for tumor cell killing effectiveness with the BT-20 human mammary carcinoma cell line as a model. Incubation of BT-20 cells with 166 Ho glass partially inhibited DNA replication and completely blocked growth in cells located within 1.0 mm of the radioactive fiber. Growth of BT-20 tumor xenografts in nude mice was dramatically inhibited by injection of 2-5 μm fragments of 166 Ho glass (200 μ Ci/tumor). The results suggest that 166 Ho glass would be an effective modality for deposition of intense β - radiation for localized internal radiotherapy of tumors.

AB - Aluminosilicate glass containing the β-emitter 166 Ho was tested for tumor cell killing effectiveness with the BT-20 human mammary carcinoma cell line as a model. Incubation of BT-20 cells with 166 Ho glass partially inhibited DNA replication and completely blocked growth in cells located within 1.0 mm of the radioactive fiber. Growth of BT-20 tumor xenografts in nude mice was dramatically inhibited by injection of 2-5 μm fragments of 166 Ho glass (200 μ Ci/tumor). The results suggest that 166 Ho glass would be an effective modality for deposition of intense β - radiation for localized internal radiotherapy of tumors.

KW - glass

KW - holmium 166

KW - unclassified drug

KW - DNA

KW - radioisotope

KW - animal experiment

KW - breast carcinoma

KW - cancer cell culture

KW - cancer graft

KW - controlled study

KW - female

KW - human cell

KW - interstitial radiation

KW - nude mouse

KW - animal

KW - brachytherapy

KW - breast tumor

KW - cancer transplantation

KW - cell survival

KW - metabolism

KW - radiation exposure

KW - Brachytherapy

KW - Breast Neoplasms

UR - https://scholarsmine.mst.edu/biosci_facwork/65

UR - http://www.ncbi.nlm.nih.gov/pubmed/1787088

U2 - 10.1016/0883-2897(91)90018-G

DO - 10.1016/0883-2897(91)90018-G

M3 - Article

C2 - 1787088

VL - 18

JO - International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology

JF - International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology

ER -

¹⁶⁶Holmium-Containing Glass for Internal Radiotherapy of Tumors

Abstract

Keywords

Disciplines

Access to Document

Other files and links

Fingerprint

Cite this