Coupling Across a DNA Helical Turn Yields a Hybrid DNA/Organic Catenane Doubly Tailed with Functional Termini

Yu Liu; Akinori Kuzuya; Ruojie Sha; Johan Guillaume; Risheng Wang; James W. Canary; Nadrian C. Seeman

doi:10.1021/ja8041096

Coupling Across a DNA Helical Turn Yields a Hybrid DNA/Organic Catenane Doubly Tailed with Functional Termini

Yu Liu
, Akinori Kuzuya
, Ruojie Sha
, Johan Guillaume
, Risheng Wang
, James W. Canary
, Nadrian C. Seeman

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

We describe the synthesis of a hybrid DNA/organic macrocycle that is prepared by formation of an amide linkage across one full turn of DNA. Formation of a catenane proved that the linkage crossed a turn rather than running along the phosphodiester backbone contour. the product, a doubly tailed catenane, contains 5'- and 3'-termini that can be functionalized further or used to incorporate the catenane structure into other DNA assemblies.

Original language	American English
Journal	Journal of the American Chemical Society
Volume	130
DOIs	https://doi.org/10.1021/ja8041096
State	Published - Aug 1 2008

Keywords

Anthracenes
Catenane
DNA
DNA Cleavage
DNA Helix
DNA Hybrid
DNA Strand
DNA Structure
DNA Template
Denaturation
Molecular Structure
Nucleic Acid Conformation
Oligonucleotide
Oligonucleotides
Stereoisomerism
Synthesis
Ultraviolet Rays

Disciplines

Chemistry

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10.1021/ja8041096License: Unspecified

https://doi.org/10.1021/ja8041096

Cite this

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title = "Coupling Across a DNA Helical Turn Yields a Hybrid DNA/Organic Catenane Doubly Tailed with Functional Termini",

abstract = " We describe the synthesis of a hybrid DNA/organic macrocycle that is prepared by formation of an amide linkage across one full turn of DNA. Formation of a catenane proved that the linkage crossed a turn rather than running along the phosphodiester backbone contour. the product, a doubly tailed catenane, contains 5'- and 3'-termini that can be functionalized further or used to incorporate the catenane structure into other DNA assemblies.",

keywords = "Anthracenes, Catenane, DNA, DNA Cleavage, DNA Helix, DNA Hybrid, DNA Strand, DNA Structure, DNA Template, Denaturation, Molecular Structure, Nucleic Acid Conformation, Oligonucleotide, Oligonucleotides, Stereoisomerism, Synthesis, Ultraviolet Rays",

author = "Yu Liu and Akinori Kuzuya and Ruojie Sha and Johan Guillaume and Risheng Wang and Canary, \{James W.\} and Seeman, \{Nadrian C.\}",

year = "2008",

month = aug,

day = "1",

doi = "10.1021/ja8041096",

language = "American English",

volume = "130",

journal = "Journal of the American Chemical Society",

issn = "1520-5126",

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TY - JOUR

T1 - Coupling Across a DNA Helical Turn Yields a Hybrid DNA/Organic Catenane Doubly Tailed with Functional Termini

AU - Liu, Yu

AU - Kuzuya, Akinori

AU - Sha, Ruojie

AU - Guillaume, Johan

AU - Wang, Risheng

AU - Canary, James W.

AU - Seeman, Nadrian C.

PY - 2008/8/1

Y1 - 2008/8/1

N2 - We describe the synthesis of a hybrid DNA/organic macrocycle that is prepared by formation of an amide linkage across one full turn of DNA. Formation of a catenane proved that the linkage crossed a turn rather than running along the phosphodiester backbone contour. the product, a doubly tailed catenane, contains 5'- and 3'-termini that can be functionalized further or used to incorporate the catenane structure into other DNA assemblies.

AB - We describe the synthesis of a hybrid DNA/organic macrocycle that is prepared by formation of an amide linkage across one full turn of DNA. Formation of a catenane proved that the linkage crossed a turn rather than running along the phosphodiester backbone contour. the product, a doubly tailed catenane, contains 5'- and 3'-termini that can be functionalized further or used to incorporate the catenane structure into other DNA assemblies.

KW - Anthracenes

KW - Catenane

KW - DNA

KW - DNA Cleavage

KW - DNA Helix

KW - DNA Hybrid

KW - DNA Strand

KW - DNA Structure

KW - DNA Template

KW - Denaturation

KW - Molecular Structure

KW - Nucleic Acid Conformation

KW - Oligonucleotide

KW - Oligonucleotides

KW - Stereoisomerism

KW - Synthesis

KW - Ultraviolet Rays

UR - https://scholarsmine.mst.edu/chem_facwork/2086

UR - https://doi.org/10.1021/ja8041096

U2 - 10.1021/ja8041096

DO - 10.1021/ja8041096

M3 - Article

C2 - 18661989

SN - 1520-5126

VL - 130

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

ER -

Coupling Across a DNA Helical Turn Yields a Hybrid DNA/Organic Catenane Doubly Tailed with Functional Termini

Abstract

Keywords

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