Antioxidant Therapy in Alzheimer's Disease: Theory and Practice

Gjumrakch Aliev; Mark E. Obrenovich; Prakash Reddy; Justin C. Shenk; Paula I. Moreira; Akihiko Nunomura; Xiongwei Zhu; Mark A. Smith; George Perry

doi:10.2174/138955708786369582

Antioxidant Therapy in Alzheimer's Disease: Theory and Practice

Gjumrakch Aliev
, Mark E. Obrenovich
, Prakash Reddy
, Justin C. Shenk
, Paula I. Moreira
, Akihiko Nunomura
, Xiongwei Zhu
, Mark A. Smith
, George Perry

Missouri University of Science and Technology

Research output: Contribution to journal › Article › peer-review

Abstract

Alzheimer disease treatment has yet to yield a successful therapy that addresses the source of the damage found in brains. Of the varied proposed theories of AD etiology, reactive oxygen species (ROS) generation is cited as a common factor. Efforts to reduce the pathology associated with ROS via antioxidants therefore offer new hope to patients suffering from this devastative disease.

Original language	American English
Journal	Mini-Reviews in Medicinal Chemistry
Volume	8
DOIs	https://doi.org/10.2174/138955708786369582
State	Published - Nov 1 2008

Keywords

Alzheimer disease
Free Radical Scavengers
animal
antioxidant
brain
drug effect
genetics
human
metabolism
oxidative stress
pathology
scavenger

Disciplines

Chemistry

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10.2174/138955708786369582License: Unspecified

https://doi.org/10.2174/138955708786369582

Cite this

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AU - Aliev, Gjumrakch

AU - Obrenovich, Mark E.

AU - Reddy, Prakash

AU - Shenk, Justin C.

AU - Moreira, Paula I.

AU - Nunomura, Akihiko

AU - Zhu, Xiongwei

AU - Smith, Mark A.

AU - Perry, George

PY - 2008/11/1

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N2 - Alzheimer disease treatment has yet to yield a successful therapy that addresses the source of the damage found in brains. Of the varied proposed theories of AD etiology, reactive oxygen species (ROS) generation is cited as a common factor. Efforts to reduce the pathology associated with ROS via antioxidants therefore offer new hope to patients suffering from this devastative disease.

AB - Alzheimer disease treatment has yet to yield a successful therapy that addresses the source of the damage found in brains. Of the varied proposed theories of AD etiology, reactive oxygen species (ROS) generation is cited as a common factor. Efforts to reduce the pathology associated with ROS via antioxidants therefore offer new hope to patients suffering from this devastative disease.

KW - Alzheimer disease

KW - Free Radical Scavengers

KW - animal

KW - antioxidant

KW - brain

KW - drug effect

KW - genetics

KW - human

KW - metabolism

KW - oxidative stress

KW - pathology

KW - scavenger

UR - https://scholarsmine.mst.edu/chem_facwork/282

UR - https://doi.org/10.2174/138955708786369582

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DO - 10.2174/138955708786369582

M3 - Article

VL - 8

JO - Mini-Reviews in Medicinal Chemistry

JF - Mini-Reviews in Medicinal Chemistry

ER -

Antioxidant Therapy in Alzheimer's Disease: Theory and Practice

Abstract

Keywords

Disciplines

Access to Document

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