A drug screen with approved compounds identifies amlexanox as a novel Wnt/β-catenin activator inducing lung epithelial organoid formation

Rita Costa; Darcy E. Wagner; Ali Doryab; Martina M. De Santis; Kenji Schorpp; Ina Rothenaigner; Mareike Lehmann; Hoeke A. Baarsma; Xueping Liu; Otmar Schmid; Monica Campillos; Ali Önder Yildirim; Kamyar Hadian; Melanie Königshoff

doi:10.1111/bph.15581

A drug screen with approved compounds identifies amlexanox as a novel Wnt/β-catenin activator inducing lung epithelial organoid formation

Rita Costa
, Darcy E. Wagner
, Ali Doryab
, Martina M. De Santis
, Kenji Schorpp
, Ina Rothenaigner
, Mareike Lehmann
, Hoeke A. Baarsma
, Xueping Liu
, Otmar Schmid
, Monica Campillos
, Ali Önder Yildirim
, Kamyar Hadian
, Melanie Königshoff

Ludwig Maximilian University of Munich
Helmholtz Zentrum München - German Research Center for Environmental Health
Lund University
University of Groningen
University of Pittsburgh

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	4026-4041
Number of pages	16
Journal	British Journal of Pharmacology
Volume	178
Issue number	19
DOIs	https://doi.org/10.1111/bph.15581
State	Published - Oct 2021
Externally published	Yes

ASJC Scopus Subject Areas

Pharmacology

Keywords

amlexanox
chronic obstructive pulmonary disease
emphysema
organoids
regenerative medicine
Wnt/β-catenin signalling pathway

Access to Document

10.1111/bph.15581

Cite this

Costa, R., Wagner, D. E., Doryab, A., De Santis, M. M., Schorpp, K., Rothenaigner, I., Lehmann, M., Baarsma, H. A., Liu, X., Schmid, O., Campillos, M., Yildirim, A. Ö., Hadian, K., & Königshoff, M. (2021). A drug screen with approved compounds identifies amlexanox as a novel Wnt/β-catenin activator inducing lung epithelial organoid formation. British Journal of Pharmacology, 178(19), 4026-4041. https://doi.org/10.1111/bph.15581

Costa, R, Wagner, DE, Doryab, A, De Santis, MM, Schorpp, K, Rothenaigner, I, Lehmann, M, Baarsma, HA, Liu, X, Schmid, O, Campillos, M, Yildirim, AÖ, Hadian, K & Königshoff, M 2021, 'A drug screen with approved compounds identifies amlexanox as a novel Wnt/β-catenin activator inducing lung epithelial organoid formation', British Journal of Pharmacology, vol. 178, no. 19, pp. 4026-4041. https://doi.org/10.1111/bph.15581

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title = "A drug screen with approved compounds identifies amlexanox as a novel Wnt/β-catenin activator inducing lung epithelial organoid formation",

keywords = "amlexanox, chronic obstructive pulmonary disease, emphysema, organoids, regenerative medicine, Wnt/β-catenin signalling pathway",

author = "Rita Costa and Wagner, \{Darcy E.\} and Ali Doryab and \{De Santis\}, \{Martina M.\} and Kenji Schorpp and Ina Rothenaigner and Mareike Lehmann and Baarsma, \{Hoeke A.\} and Xueping Liu and Otmar Schmid and Monica Campillos and Yildirim, \{Ali {\"O}nder\} and Kamyar Hadian and Melanie K{\"o}nigshoff",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors. British Journal of Pharmacology published by John Wiley \& Sons Ltd on behalf of British Pharmacological Society.",

year = "2021",

month = oct,

doi = "10.1111/bph.15581",

language = "English",

volume = "178",

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T1 - A drug screen with approved compounds identifies amlexanox as a novel Wnt/β-catenin activator inducing lung epithelial organoid formation

AU - Costa, Rita

AU - Wagner, Darcy E.

AU - Doryab, Ali

AU - De Santis, Martina M.

AU - Schorpp, Kenji

AU - Rothenaigner, Ina

AU - Lehmann, Mareike

AU - Baarsma, Hoeke A.

AU - Liu, Xueping

AU - Schmid, Otmar

AU - Campillos, Monica

AU - Yildirim, Ali Önder

AU - Hadian, Kamyar

AU - Königshoff, Melanie

PY - 2021/10

Y1 - 2021/10

KW - amlexanox

KW - chronic obstructive pulmonary disease

KW - emphysema

KW - organoids

KW - regenerative medicine

KW - Wnt/β-catenin signalling pathway

UR - https://www.scopus.com/pages/publications/85111644305

UR - https://www.scopus.com/pages/publications/85111644305#tab=citedBy

U2 - 10.1111/bph.15581

DO - 10.1111/bph.15581

M3 - Article

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AN - SCOPUS:85111644305

SN - 0007-1188

VL - 178

SP - 4026

EP - 4041

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

IS - 19

ER -

A drug screen with approved compounds identifies amlexanox as a novel Wnt/β-catenin activator inducing lung epithelial organoid formation

ASJC Scopus Subject Areas

Keywords

Access to Document

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